After providing a brief history of the American towns of Ybor and Tampa and of the local church communities at the end of the nineteenth and the beginning of the twentieth centuries, making use of a great deal of documentation, especially letters, the author describes the pastoral experience of the Salesians in the three parishes assigned to them in 1926, in which there was a considerable number of Italian immigrants. Parish schools and Sunday schools, catechism classes and pastoral activities were launched and developed, but soon financial and personnel difficulties and the not-so-easy multi-cultural situation forced the Salesians to leave the parishes to the care of the Redemptorists (1934). The note is intended simply to provide useful material for further studies.